Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease

摘要

An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).

主权项

1. A method for treating or reducing a risk of sepsis and necrotizing enterocolitis (NEC), the method comprising:
administering to an individual in need thereof an effective amount of a composition comprising one or more alpha-1,2 fucosyl glycans, wherein the individual has a level of at least one antigen that differs from a predetermined value or is outside a predetermined range of values, the at least one antigen being selected from the group consisting of H-1, H-2, Lewisb, Lewisy, sulfated or sialylated H-1, sulfated or sialylated H-2, sialylated Lewisa, sulfated or sialylated Lewisb, and sulfated or sialylated Lewisy, and wherein the one or more alpha-1,2 fucosyl glycans are purified, synthesized chemically, or synthesized enzymatically using engineered microorganisms.