Use of secretor, Lewis and sialyl antigen levels in clinical samples as predictors of risk for disease

摘要

An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).

主权项

1. A method for treating necrotizing enterocolitis (NEC), the method comprising:
administering to an infant having NEC an effective amount of a composition comprising one or more alpha-1,2 fucosyl glycans, wherein the infant is a premature infant or an infant having a birth weight of less than 2500 grams, and wherein the one or more alpha-1,2 fucosyl glycans are either purified from a natural source or chemically synthesized.