Graduated estrogen contraceptive

摘要

A multiphasic estrogenic/progestogenic contraceptive regimen that provides for the reduction or elimination of estrogen in the initial phase is disclosed. Also described is a contraceptive kit that may be used to practice the method of the invention.

主权项

1. A multiphase combination and contraceptive kit comprising a package containing daily dosages of:
(a) a Phase I composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 0.5 to about 5 mcg of ethinyl estradiol; (b) a Phase II composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 10 to about 50 mcg of ethinyl estradiol; and (c) a Phase III composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 25 to about 50 mcg of ethinyl estradiol, wherein the amount of estrogen in the Phase III composition is greater than the amount of estrogen in the Phase II composition by at least an amount equivalent to 5 mcg ethinyl estradiol;
wherein the kit contains about 5 to about 9 dosages of the Phase I composition; about 5 to about 9 dosages of the Phase II composition; about 8 to about 12 dosages of the Phase III composition and about 1 to about 4 dosages of a Phase IV composition which contains ferrous fumarate or is a placebo; and the total number of dosages from Phase I, II, III and IV in the kit is 28.