ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS

摘要

THE PRESENT INVENTION IS DIRECTED TO NOVEL WATER-SOLUBLE PHARMACEUTICALLY ACCEPTABLE, CRYSTALLINE ADDITION SALTS OF (I) AN AMINE CONTAINING ONE OR MORE HYDROXYL AND/OR CARBOXYLIC GROUPS WITH (II) AMINO NICOTINIC ACID DERIVATIVES OF FORMULA (I) WHEREIN R?, R?, R? AND R? INDEPENDENTLY REPRESENT GROUPS SELECTED FROM HYDROGEN ATOMS, HALOGEN ATOMS, C?-? ALKYL GROUPS WHICH MAY BE OPTIONALLY SUBSTITUTED BY 1, 2 OR 3 SUBSTITUENTS SELECTED FROM HALOGEN ATOMS AND HYDROXY GROUPS, AND C?-? ALKOXY GROUPS WHICH MAY BE OPTIONALLY SUBTITUTED BY 1, 2 OR 3 SUBSTITUENTS SELECTED FROM HALOGEN ATOMS AND HYDROXY GROUPS, AND PHARMACEUTICALLY ACCEPTABLE SOLVATES THEREOF.