Method for manufacturing hydrophilic silicone macromer

摘要

A method for manufacturing a hydrophilic silicone macromer is provided. A hydrosilylation between a Si—H bond of a polysiloxane and a C═C bond of a hydrophilic mononmer is performed by using a rhodium-containing catalyst to form the polysiloxane having a hydrophilic side chain having an amide group or a phosphoryl choline group. After performing an end-capping reaction, the hydrophilic silicone macromer is formed.

主权项

1. A method for manufacturing a hydrophilic silicone macromer, comprising the steps of:
performing a ring-opening insertion, wherein a cyclic siloxane and a cyclic hydrogen siloxane are subject to a ring-opening reaction, and then are inserted into an asymmetrically end-capped polydialkylsiloxane having a terminal reactive hydrogen to form an asymmetrically end-capped polysiloxane having a silicon-hydrogen (Si-H) bond, in which the terminal reactive hydrogen is derived from a hydroxyl group or an amino group; performing a hydrosilylation between the Si-H bond of the asymmetrically end-capped polysiloxane and a C═C bond of a hydrophilic monomer by using a rhodium-containing catalyst to form an asymmetrically end-capped polysiloxane intermediate having a hydrophilic side chain, wherein the hydrophilic monomer has an amide group or a phosphoryl choline group; and performing an end-capping reaction between the terminal reactive hydrogen of the asymmetrically end-capped polysiloxane intermediate and an electrophilic group of an ethylenically unsaturated compound to form the hydrophilic silicone macromer having only one ethylenically unsaturated group.