Selective androgen receptor modulators

摘要

This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.

主权项

1. A compound according to formula I: wherein Rx is CN, Cl, Br, or NO2; Ry is CH3, CF3, or halogen; Rz is hydrogen or optionally C1-3 alkyl, C2-3 alkenyl, C1-3 hydroxyalkyl, C1-3 haloalkyl, NO2, NH2, OMe, halogen or OH; P1 is hydrogen or a metabolically labile group; Ra and Rb are each independently selected from hydrogen or C1-C3 alkyl; and X is O; or pharmaceutically acceptable salts thereof.