| 主权项 |
1. A salt or cocrystal of
(a) (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b1) at least one acid selected from the group consisting of embonic acid, (2S,3S)-dibenzoyltartaric acid, sebacic acid, and 1-hydroxy-2-naphthoic acid, or (b2) at least one acid selected from the group consisting of nicotinic acid, hydrogen bromide, fumaric acid, and malonic acid wherein the salt or cocrystal of component (a) and component (b1) or the salt or cocrystal of component (a) and component (b2) is present in crystalline form, and wherein said crystalline form is selected from the group consisting of:
a salt or cocrystal of embonic acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 7.94±0.20 (2θ), 10.40±0.20 (2θ), 14.25±0.20 (2θ), 17.18±0.20 (2θ) and 18.77±0.20 (2θ) or at least one or more X-ray diffraction peaks selected from the group consisting of 6.00±0.20 (2θ), 11.96±0.20 (2θ) and 17.61±0.20 (2θ);a hemi salt or cocrystal of (2S,3S)-dibenzoyltartaric acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 9.35±0.20 (2θ), 12.22±0.20 (2θ), 13.41±0.20 (2θ), 14.00±0.20 (2θ), 17.89±0.20 (2θ), 18.28±0.20 (2θ), 18.73±0.20 (2θ), 19.53±0.20 (2θ), 19.98±0.20 (2θ), 23.19±0.20 (2θ) and 24.33±0.20 (2θ);a salt or cocrystal of sebacic acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 12.16±0.20 (2θ), 15.31±0.20 (2θ), 16.88±0.20 (2θ), 18.90±0.20 (2θ), 22.66±0.20 (2θ), 23.08±0.20 (2θ) and 25.46±0.20 (2θ);a salt or cocrystal of 1-hydroxy-2-naphthoic acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 13.59±0.20 (2θ), 13.97±0.20 (2θ), 15.36±0.20 (2θ), 18.04±0.20 (2θ), 19.75±0.20 (2θ), 19.98±0.20 (2θ), 20.52±0.20 (2θ), 24.37±0.20 (2θ) and 26.09±0.20 (2θ);a salt or cocrystal of nicotinic acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 12.60±0.20 (2θ), 15.61±0.20 (2θ) and 22.82±0.20 (2θ) or at least one or more X-ray diffraction peaks selected from the group consisting of 10.34±0.20 (2θ), 12.14±0.20 (2θ), 22.38±0.20 (2θ), 23.65±0.20 (2θ) and 26.11±0.20 (2θ);a salt or cocrystal of hydrobromic acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 9.93±0.20 (2θ), 14.39±0.20 (2θ), 15.22±0.20 (2θ), 17.60±0.20 (2θ), 20.81±0.20 (2θ), 21.61±0.20 (2θ), 24.37±0.20 (2θ), 24.73±0.20 (2θ), 25.19±0.20 (2θ), 27.14±0.20 (2θ), 27.94±0.20 (2θ), 29.00±0.20 (2θ) and 30.75±0.20 (2θ);a salt or cocrystal of malonic acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 8.75±0.20 (2θ), 11.85±0.20 (2θ), 13.74±0.20 (2θ), 16.78±0.20 (2θ), 18.09±0.20 (2θ), 19.17±0.20 (2θ), 16.65±0.20 (2θ), 20.45±0.20 (2θ), 21.66±0.20 (2θ), 24.80±0.20 (2θ) and 25.55±0.20 (2θ); anda hemi salt or cocrystal of fumaric acid and (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol having at least one or more X-ray diffraction peaks selected from the group consisting of 11.86±0.20 (2θ), 15.26±0.20 (2θ), 16.00±0.20 (2θ), 16.21±0.20 (2θ), 17.52±0.20 (2θ), 21.75±0.20 (2θ), 22.35±0.20 (2θ), 24.57±0.20 (2θ) and 25.21±0.20 (2θ). |
