Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings

摘要

The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

主权项

1. A compound having the formula: wherein R1 is H, a branched or straight chain C1 to C5 alkyl, or each R2 is independently H or  wherein R4 is a branched or unbranched C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, aryloxy, benzyl, or phenyl; and each R3 is independently wherein each R5 is independently H, a branched or unbranched C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, or benzyl; or a salt or hydrate of said compound.