Cycloalkylamne derivatives

摘要

Provided is a therapeutic agent for hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like, which has a CaSR activating (agonist) action. A compound represented by the following general formula (1):;
[wherein, Ar which is a partial structure in the general formula (1) represents a phenyl group or a naphthyl group; R1a and R1b are the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; R2a and R2b are the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; A represents a single bond, an oxygen atom, or the like; B represents a single bond, a C1-C4 alkanediyl group, or the like; Z represents a carboxyl group or a tetrazolyl group; and m represents an integer of 1 to 3] or a pharmacologically acceptable salt thereof.

主权项

1. A compound of general formula (1): or a pharmacologically acceptable salt thereof, wherein, the partial structure of formula (2):in the general formula (1) represents a naphthyl group;
R1a and R1b are the same or different from each other, and represent a hydrogen atom, a halogeno group, a C1-C6 alkyl group or a C1-C6 alkoxy group; R2a and R2b are the same or different from each other, and represent a hydrogen atom, a halogeno group, a C1-C6 alkyl group, a halogeno C1-C6 alkyl group, a hydroxyl group, or a C1-C6 alkoxy group; A represents a single bond, an oxygen atom, a —NR3— group, a —NR3C(═O)— group, a —NR3—S(O)2— group or a —S(O)n— group, wherein R3 represents a hydrogen atom, a C1-C4 alkyl group or a C1-C4 acyl group, and n represents 0, 1 or 2; B represents a C1-C4 alkanediyl group or a C3-C4 cycloalkanediyl group; Z represents a carboxy group; and m is 2.