发明名称 Dendrimers and methods of preparing same through proportionate branching
摘要 The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance.
申请公布号 US9133114(B2) 申请公布日期 2015.09.15
申请号 US201313752482 申请日期 2013.01.29
申请人 UNIVERSITY OF MARYLAND, BALTIMORE;UNIVERSITY OF MARYLAND, COLLEGE PARK 发明人 Yu Yihua (Bruce);Yue Xuyi
分类号 A61K51/06;C07C323/12;A61K49/12 主分类号 A61K51/06
代理机构 Moore & Van Allen, PLLC 代理人 Fuierer Marianne;Moore & Van Allen, PLLC
主权项 1. A dendrimer comprising a generation (G) branching structure comprising a core, branches and periphery ends, wherein length of the branches increases exponentially from the periphery ends to the core and the number of branches increases exponentially from the core to the periphery ends, wherein the number of branches in a nth layer is defined as mn and the number of bonds between the nth layer and n−1 layer is defined as ln, wherein n is defined as a value of 1≦n≦G, wherein the increasing number of mn from the core to the periphery is defined by the formula mn=a×mn-1 and the increasing number of ln from the periphery to the core is defined by the formula ln-1=b×ln, wherein a is a branch multiplier for growing the number of branches and b is the branch length multiplier for growth of the length of the branches and wherein the length multiplier b satisfies 1≦b≦a.
地址 Baltimore MD US