发明名称 |
Reverse thermal gels and uses therefor |
摘要 |
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower temperature to a higher temperature, they gel. These gels are useful in drug delivery when complexed with an active agent. For example the compositions can be used for intraocular injection of active agents, such as anti-angiogenic agents for treatment of a maculopathy or retinitis. |
申请公布号 |
US9132199(B2) |
申请公布日期 |
2015.09.15 |
申请号 |
US201113581518 |
申请日期 |
2011.03.04 |
申请人 |
University of Pittsburgh—Of the Commonwealth System of Higher Education |
发明人 |
Friberg Thomas R.;Park Daewon;Wang Yadong |
分类号 |
A61K47/48;C08G18/83;A61K9/00;A61K9/06;A61K47/34 |
主分类号 |
A61K47/48 |
代理机构 |
The Webb Law Firm |
代理人 |
The Webb Law Firm |
主权项 |
1. A reverse thermal gel composition comprising a triblock copolymer, or a pharmaceutically acceptable salt thereof, having the structure B-A-B in which A is one of a polyurethane or poly(ester urethane) group that comprises one or more pendant amine groups, blocked amine groups or active agents and B is a hydrophilic block, wherein the composition is a gel at 35° C.-40° C. and a liquid solution at a lower temperature, and wherein A is a copolymer of a diol and a diisocyanate. |
地址 |
Pittsburgh PA US |