Test of insulin as a drug to reduce restenosis of vessels

摘要

Methods, compositions, and devices for treating restenosis are described. In accord with the invention, a composition containing CTGF and insulin is applied to blood vessels and restenosis is reduced or prevented.

主权项

1. A method of preventing restenosis, the method comprising:
contacting to an external surface of a blood vessel having an intravascular wound a gel or semi-solid composition comprising connective tissue growth factor (CTGF) and insulin in therapeutically effective amounts to prevent restenosis, wherein the composition suppresses neo-intimal growth and increases adaptive remodeling in the vessel relative to a blood vessel having an intravascular wound that is not contacted to the composition whereby restenosis is prevented, and wherein an effective amount of insulin is about 0.3 μg/mL to about 5 μg/mL, and an effective amount of CTGF is about 0.1 μg/mL to about 0.5 μg/mL.