2-methoxy-pyridin-4-yl-derivatives

摘要

The invention relates to pyridine derivatives of Formula (I);wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

主权项

1. A compound of the Formula (I), wherein A represents wherein the asterisks indicate the bond that is linked to the pyridine group of Formula (I); R1 represents cyclopentyl; R2 represents methyl, and R4 represents ethyl or chloro; or R2 represents methoxy, and R4 represents chloro; R3 represents —OCH2COOH, —OCH2CH2CH2COOH, —OCH2CONHCH2CH2OH, —OCH2CH2CH2CONHCH2CH2OH, —OCH2—(CH2)n—NH—(CH2)m—COOH, —OCH2—(CH2)n—N(CH3)—(CH2)m—COOH, 2-[(azetidine-3-carboxylic acid)-1-yl]-ethoxy, 2-[(pyrrolidin-3-carboxylic acid)-1-yl]-ethoxy, 3-[(azetidine-3-carboxylic acid)-1-yl]-propoxy, 3-[(pyrrolidin-3-carboxylic acid)-1-yl]-propoxy, —OCH2CH(OH)—CH2NH—CH2COOH, —OCH2CH(OH)—CH2NH—CH2CH2COOH, —OCH2CH(OH)—CH2N(CH3)—CH2COOH, —OCH2CH(OH)—CH2N(CH3)—CH2CH2COOH, 3-[(azetidine-3-carboxylic acid)-1-yl]-2-hydroxy-propoxy, 2-hydroxy-3-[(pyrrolidin-3-carboxylic acid)-1-yl]-propoxy, —OCH2—(CH2)n—NH—CH2CH2OH, —OCH2—(CH2)n—NH—CH(CH2OH)2, —OCH2—(CH2)n—NH—CH2CH(OH)—CH2OH, —OCH2CH(OH)—CH2NH—CH2CH2OH, —OCH2CH(OH)—CH2NH—CH(CH2OH)2, —OCH2—(CH2)k—NH—CO—CH2OH, —OCH2—(CH2)n—NH—CO—CH2COOH, —OCH2—(CH2)n—NH—CO—CH2CH2COOH, —OCH2CH(OH)—CH2NH—CO—(CH2)—COOH, —OCH2—(CH2)n—N(CH3)—CO—CH2OH, —OCH2—(CH2)n—N(CH3)—CO—CH2COOH, or —OCH2—(CH2)n—N(CH3)—CO—CH2CH2COOH; n independently represents 1 or 2; m independently represents 1, 2, or 3; and k represents 1 or 2; or a salt thereof.