Stilbene analogs and methods of treating cancer

摘要

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

主权项

1. A method of treating liver cancer or colon cancer, the method comprising administering to a patient in need of such treatment an effective amount of a compound according to formula (I):
X—Ar1—CRa═CRb—Ar2  (I) or a pharmaceutically acceptable salt thereof, wherein Ra and Rb are independently H, alkyl, halo, alkoxy, cyano; X represents at least one halogen on Ar1; Ar1 is phenyl and Ar2 is pyridyl; provided that Ar2 contains at least one NRcRdZ substituent on Ar2 where Rc is H, alkyl, alkoxy, aryl, heteroaryl, Rd is an unsubstituted alkyl group, Z is an unshared pair of electrons, H, alkyl, oxygen.