| 发明名称 | Delivery system comprising a silicon-containing material | ||
| 摘要 | A composition comprising nanoparticles of a hydrolysable silicon-contain material for use as a delivery system for a bioactive ingredient, wherein surface of the silicon-containing material is associated with a stabilizing agent which modifies the rate of hydrolysis of the silicon-contain material and/or inhibits the rate of orthosilicic acid polymerization and a method of promoting the controlled release of orthosilicic acid on degradation of a composition comprising nanoparticles of a hydrolysable silicon-contain material, the method involving the treatment of the surface of the silicon-containing material with a stabilizing agent to modify the rate of hydrolysis of the silicon-containing material and/or inhibit the rate of orthosilicic acid polymerization. | ||
| 申请公布号 | US9132083(B2) | 申请公布日期 | 2015.09.15 |
| 申请号 | US201013387766 | 申请日期 | 2010.07.30 |
| 申请人 | SISAF Ltd. | 发明人 | Saffie-Siebert Roghieh |
| 分类号 | A61K8/25;A61K33/00;A61Q19/00;A61K9/00;A61K8/02;A61K8/55;A61K9/51 | 主分类号 | A61K8/25 |
| 代理机构 | Kramer Levin Naftalis & Frankel LLP | 代理人 | Kramer Levin Naftalis & Frankel LLP |
| 主权项 | 1. A composition comprising nanoparticles of a solid, hydrolysable silicon-containing semiconductor material that includes at least 50 wt % of elemental silicon for use as a delivery system for a bioactive ingredient, wherein the surface of the silicon-containing material is associated with a stabilizing agent which forms surface linkages to the silicon-containing material to (a) modify the rate of hydrolysis of the silicon-containing material, (b) stabilise orthosilicic acid in solution by inhibiting the rate of orthosilicic acid polymerisation, or (a) and (b). | ||
| 地址 | GB | ||