2,4-pyridinediamine compounds and their uses

摘要

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

主权项

1. A compound according to Formula (I)or a salt thereof, wherein:
one of R2 and R4 is a phenyl monosubstituted with (C1-C6) alkyl, —ORa, —O—C(O)ORa, —O—(CH2)m—C(O)ORa, —C(O)ORa, —O—(CH2)m—NRcRc, —O—C(O)NRcRc, —O—(CH2)m—C(O)NRcRc, —O—C(NH)NRcRc, —O—(CH2)m—C(NH)NRcRc, —NH—(CH2)m—NRcRc or —[NHC(O)]Rd; the other of R2 and R4 is a phenyl monosubstituted or disubstituted with R8; R2 and R4 are different; R5 is fluoro, —CN, or (C1-C3) haloalkyl; each R8 is independently Ra, Rb, or Ra substituted with one Ra or Rb; each Ra is H, (C1-C6) alkyl, or 3-8 membered cycloheteroalkyl; each Rb is —ORa, —OCF3, —NRcRc, halogen, —CF3, —CN, —NO2, —N3, —SO2NRcRc, —C(O)Ra, —C(O)ORa, —C(O)NRcRc, or —C(NH)NRcRc; each Rc is independently Ra or, alternatively, two Rc are taken together with the nitrogen atom to which they are bonded to form a 5 or 6-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the same or different additional heteroatoms; each Rd is independently Ra; and each m is independently an integer from 1 to 2.