| 发明名称 | Vitronectin-derived cell culture substrate and uses thereof | ||
| 摘要 | Vitronectin-derived cell culture substrates and methods of using the same for culturing pluripotent stem cells are presented. | ||
| 申请公布号 | US9133266(B2) | 申请公布日期 | 2015.09.15 |
| 申请号 | US201213464235 | 申请日期 | 2012.05.04 |
| 申请人 | Wisconsin Alumni Research Foundation | 发明人 | Thomson James A.;Hou Zhonggang;Chen Guokai |
| 分类号 | C12N5/071;C07K14/78;C12N5/0735;C12N5/074 | 主分类号 | C12N5/071 |
| 代理机构 | Quarles & Brady LLP | 代理人 | Quarles & Brady LLP |
| 主权项 | 1. A method for maintaining pluripotent stem cells in culture, the method comprising culturing pluripotent stem cells on a substrate comprising one or both of the polypeptides selected from the group consisting of residues 43 to 378 of SEQ ID NO: 1 and residues 45 to 378 of SEQ ID NO: 1, whereby the substrate maintains the cultured pluripotent stem cells as a substantially undifferentiated cell population for at least 20 passages. | ||
| 地址 | Madison WI US | ||