Macrocyclic kinase inhibitors

摘要

Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.;

主权项

1. A compound of Formula I: wherein: X is N or CH; A1 is optionally substituted phenylene or optionally substituted 5-6heteroaryl; A3 is optionally substituted 5-6heterocyclic; L2 is —O— or a bond; L3 is optionally substituted C2-6aliphatic; L4 is optionally substituted C1-2aliphatic; Q1 to Q4 are independently N,N-oxide, or optionally substituted CH; when Q1 and Q4 are independently CH or N, an optionally substituted 5-6cyclic containing one or more heteroatoms is optionally fused to Ring A2 at Q1 and Q4; R1, Ra, and Rb are each independently H or an optional substituent; and R4 is OH, C1-4aliphatic, —OC1-3aliphatic, 3-6carbocyclic, or 4-6heterocyclic; or a pharmaceutically acceptable salt thereof.