发明名称 |
SURFACTANT PROTEIN D FOR THE PREVENTION AND DIAGNOSIS OF PULMONARY EMPHYSEMA |
摘要 |
<p>Surfactant protein D(SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (-/-) mice. The SP-D (-/-) deficiency caused inflammation, increased oxidant production by isolated alveolar macrophages, abnormal surfactant structure and levels, and decreased SP-A expression. Therefore, disclosed is the SP-D (-/-) mouse as an excellent model for emphysema. Also included are models for testing emphysema therapies in the mouse model, methods for using SP-D protein or DNA as a treatment for emphysema and pulmonary infections, and diagnosis.</p> |
申请公布号 |
CA2749553(C) |
申请公布日期 |
2015.09.15 |
申请号 |
CA19992749553 |
申请日期 |
1999.10.20 |
申请人 |
CHILDREN'S HOSPITAL MEDICAL CENTER |
发明人 |
WHITSETT, JEFFREY A.;KORFHAGEN, THOMAS R. |
分类号 |
A01K67/027;A61K38/17;A61K9/12;A61K35/76;A61K48/00;A61P11/00;C07K14/47;C07K14/785;C07K16/18;C12N15/09;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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