COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY

摘要

COMPOUNDS OF GENERAL FORMULA (I) WHEREIN W IS CHLORO OR FLUORO; R1 IS PHENYL OPTIONALLY SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM HALO,-CN, -C1-C6 ALKYL, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, AND -O(CH2)pO(CH2)qOR2 WHEREIN EACH R2 IS INDEPENDENTLY HYDROGEN, -C1-C6 ALKYL, -C3-C8 CYCLOALKYL, ARYL OR HETEROARYL; EACH R3 IS INDEPENDENTLY, -C1-C6 ALKYL, -C3-C8 CYCLOALKYL, ARYL OR HETEROARYL; p AND q ARE EACH INDEPENDENTLY AN INTEGER FROM 1 TO 3; AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, HYDRATES, SOLVATES, COMPLEXES OR PRODRUGS ARE USEFUL IN ORALLY ADMINISTRABLE COMPOSITIONS FOR THE TREATMENT OF ALLERGIC DISEASES SUCH AS ASTHMA, ALLERGIC RHINITIS AND ATOPIC DERMATITIS.