| 摘要 |
The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer. |
| 主权项 |
1. An isolated nucleic acid molecule encoding
a) the heavy chain of a monoclonal anti-human CCL20 antibody or an antigen-binding portion thereof, wherein the complementarity determining region (CDR) 1, CDR2, and CDR3 of said heavy chain comprise the amino acid sequences shown in
i) SEQ ID NOS: 60, 64, and 67, respectively, orii) SEQ ID NOS: 77, 79, and 67, respectively; and b) the light chain of the monoclonal anti-human CCL20 antibody or antigen-binding portion, wherein the CDR1, CDR2, and CDR3 of said light chain comprise the amino acid sequences shown in
i) SEQ ID NOS: 70, 73, and 75, respectively, orii) SEQ ID NOS: 71, 73, and 75, respectively. |
