Methods and dressings for sealing internal injuries

摘要

Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.

主权项

1. A device for treating wounded internal tissue in a mammal comprising:
(a) an applicator; and (b) a haemostatically effective amount of a casted haemostatic material, wherein said casted haemostatic material consisting essentially of a substantially homogeneous mixture of a fibrinogen component and a fibrinogen activator, wherein said fibrinogen component is present in an amount between 26 to about 450 mg per square centimeter of the surface intended to contact the wounded internal tissue being treated and wherein the fibrinogen activator is employed between about 0.0087-1.000 mg fibrinogen component, and wherein said fibrinogen component and fibrinogen activator are cooled to about 4° C.+/−2° C. before casting.