发明名称 Substituted triazine derivatives and use thereof as stimulators of soluble guanylate cyclase
摘要 The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
申请公布号 US9133191(B2) 申请公布日期 2015.09.15
申请号 US201314371054 申请日期 2013.01.08
申请人 BAYER INTELLECTUAL PROPERTY GMBH 发明人 Follmann Markus;Stasch Johannes-Peter;Redlich Gorden;Griebenow Nils;Wunder Frank;Lang Dieter
分类号 C07D471/04;A61K31/53;A61K45/06 主分类号 C07D471/04
代理机构 Buchanan Ingersoll & Rooney PC 代理人 Buchanan Ingersoll & Rooney PC
主权项 1. A compound of the formula (I)in which the ring Q is a group of the formulawhere * is the attachment site to —CH2-R2, ** is the attachment site to the triazine ring, R1a is hydrogen or methyl, R1b is hydrogen or fluorine, R1c is hydrogen or chlorine, A1 is N or CH, A3 is N, CH or C—F, R2 is 3,3,3-trifluoroprop-1-yl, 2,2,3,3-tetrafluoroprop-1-yl, 2,2,3,3,3-pentafluoroprop-1-yl, phenyl or pyridyl, where phenyl is substituted by 1 to 3 fluorine substituents,andwhere pyridyl may be substituted by 1 fluorine substituent, R3 is difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, cyclopropyl, cyclobutyl, cyclopentyl, methylsulphonylamino, methoxycarbonylamino, phenyl, pyrazolyl, oxazolyl or pyridyl, where (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, cyclopropyl, cyclobutyl, cyclopentyl, difluoromethoxy, trifluoromethoxy, methoxy and ethoxy,andwhere phenyl, pyrazolyl, oxazolyl and pyridyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, chlorine, difluoromethyl, trifluoramethyl, methyl, ethyl, cyclopropyl, cyclobutyl, cyclopentyl, trifluoromethoxy, methoxy and ethoxy, R4 is hydroxy or amino, or a salt thereof.
地址 Monheim DE