| 摘要 |
The present invention relates to a method for preparing nitrogen compounds using carbon dioxide, and to the use of the method in the production of vitamins, pharmaceutical products, adhesives, acrylic fibers, synthetic leathers, pesticides, herbicides, antifungal agents and fertilizers. The invention also relates to a method for producing vitamins, pharmaceutical products, adhesives, acrylic fibers, synthetic leathers, pesticides, herbicides, antifungal agents and fertilizers, which includes a step of preparing nitrogen compounds using the method of the invention. The invention further relates to a method for preparing labelled nitrogen compounds using carbon dioxide and to the uses thereof. |
| 主权项 |
1. A process for the preparation of nitrogenous compounds of formula (I): in which:
R1 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a heterocycle, a carbonyl (—CO—) group, a silyl group, a siloxy group or an amino group, said alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, silyl, siloxy and amino groups being optionally substituted,R1 optionally comprises an H, C, N, O, F, Si and/or S as defined below;H represents a hydrogen atom (1H), deuterium (2H) or tritium (3H);C represents a carbon atom (12C) or a 11C, 13C or 14C isotope;N represents a nitrogen atom (14N) or a 15N isotope;O represents an oxygen atom (16O) or an 18O isotope;F represents a fluorine atom (19F) or a 18F isotope;Si represents a silicon atom (28Si) or a 29Si or 30Si isotope;S represents a sulfur atom (32S) or a 33S, 34S or 36S isotope;E represents an R5R6N— or R7O— group with
R5, R6 and R7 representing, independently of one another, a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a heterocycle, a (—(CO)—) group, a silyl group, a siloxy group or an amino group, said alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, silyl, siloxy and amino groups being optionally substituted, orR5 and R6, taken together with the nitrogen atom to which they are bonded, form an optionally substituted heterocycle, orR1 and R5, taken together with the two nitrogen atoms to which they are respectively bonded, form an optionally substituted heterocycle, orR1 and R7, taken together with the nitrogen atom and oxygen atom to which they are respectively bonded, form an optionally substituted heterocycle,R5, R6 and R7 optionally comprise an H, C, N, O, F, Si and/or S as defined above,R1, N and O being as defined above; comprising a step of reacting an amine of formula (II): in which R1 and N are as defined above, with CO2, in which C and O are as defined above, in the presence: of a catalyst, of a silane compound of formula (III): in which:
H is as defined above,R2, R3 and R4 represent, independently of one another, a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a silyl group, a siloxy group, an aryl group or an amino group, said alkyl, alkenyl, alkynyl, alkoxy, silyl, siloxy, aryl and amino groups being optionally substituted, orR4 is as defined above and R2 and R3, taken together with the silicon atom to which they are bonded, form an optionally substituted silylated heterocycle, and of a nucleophilic agent of formula (IV):
E-H (IV) in which E is as defined above and H is a hydrogen atom. |
