Kinase inhibitor compounds

摘要

The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer.

主权项

1. A method of treating cancer in a subject comprising administering to the subject identified as in need thereof a compound selected from the group consisting of:
2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one; 3-[5-[(4-oxo-4-phenyl-butan-2-ylidene)amino]pentylimino]-1-phenyl-butan-1-one (G13); 2-(diethylaminomethyl)-4-[4-[3-(diethylaminomethyl)-4-hydroxy-phenyl]hex-3-en-3-yl]phenol (G6); 2-dibutoxyphosphoryloxypentanenitrile (G31); ytterbium(+3) cation trihydroxide (G33); 4-[(1S)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]benzonitrile (G40); G6 lead compound or a salt, hydrate or solvate thereof ; wherein said cancer is selected from the group consisting of leukemias, lymphomas, myelomas, myeloproliferative disorders, pancreatic cancer, and glioma.