Method of treatment of renal dysfunctions with chimeric natriuretic peptides

摘要

This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing diuretic and/or natriuretic activities within a mammal.

主权项

1. A method for treating a mammal having a renal dysfunction, wherein said method comprises administering to said mammal a polypeptide between 37 and 47 amino acid residues in length, wherein said polypeptide comprises an amino acid sequence that aligns to the sequence set forth in SEQ ID NO:1 with five, four, three, two, or one amino acid addition(s), deletion(s), substitution(s), or combinations thereof, and wherein said polypeptide is administered in an amount effective to reduce the severity of a symptom of said renal dysfunction.