发明名称 |
BETA-L-2´-DEOXYNUKLEOTIDER TIL BEHANDLING AF RESISTENTE HBV-STAMMER OG KOMBINATIONSTERAPIER |
摘要 |
<p>It has been discovered thatβ-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering aβ-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. In addition, a method for preventing lamivudine resistant HBV (M552V) mutation from occurring in a naïve host is provided that includes administering aβ-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. A method for preventing and/or suppressing the emergence of the HBV double mutant (L528M/M552V) in a host is also provided that includes administering aβ-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug.</p> |
申请公布号 |
DK1572095(T3) |
申请公布日期 |
2015.09.14 |
申请号 |
DK20030770334T |
申请日期 |
2003.09.15 |
申请人 |
NOVARTIS AG |
发明人 |
STANDRING, DAVID;SOMMADOSSI, JEAN-PIERRE;SEIFFER, MARIA;PATTY, APRIL, L. |
分类号 |
A61K31/70;A61K31/00;A61K31/7068;A61K31/7072;A61K31/7076;A61K38/21;A61K45/06;A61P31/12;A61P31/20 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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