The present invention provides mammalian cell lines that have been genetically engineered causing such cell lines to be resistant to viral entry and/or propagation, and provides methods of using said cell lines to reduce or prevent viral contamination of biologic production systems.
申请公布号
WO2015134488(A1)
申请公布日期
2015.09.11
申请号
WO2015US18474
申请日期
2015.03.03
申请人
SIGMA-ALDRICH CO. LLC
发明人
LIN, NAN;MASCARENHAS, JOAQUINA;CHANG, AUDREY;ONIONS, DAVID;GEORGE, HENRY;KAYSER, KEVIN