HEPARIN EMBEDDED CELLULOSE ACETATE PHTHALATE CORE/CORONA NANOPARTICLES OF 5-FLUOROURACIL FOR TARGETED DELIVERY TO LUNG CANCER

摘要

The present invention relates to a method for targeted effectively delivering an anticancer drug (i.e. 5-FU) into cancer cells by encapsulated the anticancer drug to heparin anchored cellulose acetate phthalate (HEC) nanoparticles. HEC nanoparticles according to the present invention, HEC nanoparticles were selectively deliver 5-FU to lung cancer as heparin and other related compounds have been proved to modulate the activity of Tumor Necrosis Factor and NF-?B, which are involved in apoptotic cell death and heparin as ligands for Anaplastic Lymphoma Kinase (ALK). HEC nanoparticles can also allow for controlled and/or sustained release of 5-FU in vivo.