A loop dissolution system specifically suited for dissolving uranium compounds in an acidic bath that continually circulates the acid over the uranium compound to be dissolved. The dissolution system includes an upper material feed dissolution plate on which the material to be dissolved is fed, a lower mixing and dissolution ring and a drop pipe system connecting and establishing fluid communication between the upper material feed dissolution plate and the lower mixing and dissolution ring. A pump for circulating the acidic fluid has an intake from the lower mixing and dissolution ring and an outlet that directs a first portion of a fluid to the upper material feed dissolution plate and a second portion of the fluid back into the lower mixing and dissolution ring to circulate the material suspended in the fluid within the lower mixing and dissolution ring to promote turbulence and facilitate dissolution.