发明名称 |
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR -SPECIFIC ANTIBODIES AND USES THEREOF |
摘要 |
The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF lR)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated. |
申请公布号 |
WO2015131258(A1) |
申请公布日期 |
2015.09.11 |
申请号 |
WO2014CA00862 |
申请日期 |
2014.12.04 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
STANIMIROVIC DANICA;KEMMERICH KRISTIN;HAQQANI, ARSALAN S.;SULEA, TRAIAN;ARBABI-GHAHROUDI, MEHDI;MASSIE BERNARD;GILBERT RÉNALD |
分类号 |
C07K16/28;A61K39/395;A61K49/00;C07K16/46;C07K17/00;C12N15/13;G01N33/53 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|