1-CYCLOPROPYL-6-FLUORO-7-(8-METHOXYIMINO-2,6-DIAZA-SPIRO[3,4]OCT-6-YL)-4-OXO-1,4-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID D-ASPARTATE HYDRATES AND AN ANTIBACTERIAL PHARMACEUTICAL COMPOSITIONS COMPRISING THEIR HYDRATES

摘要

The present invention relates to 1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3,4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid D-aspartate hydrates and an antibacterial composition comprising their hydrates. The present invention provides stable zabofloxacin D-aspartate hydrates wherein adsorption and desorption of water hardly occur, and provides specifically zabofloxacin D-aspartate sesquihydrate. Because the zabofloxacin D-aspartate hydrates according to the present invention hardly absorb moisture, they have an outstanding physicochemical property. Therefore, the drugs comprising zabofloxacin D-aspartate hydrate of the present invention do not easily break, especially in its tablet form, and changes little in the content of the main ingredient, thus exhibiting an excellent pharmaceutical stability.