METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS FOR AUTOIMMUNE DISEASE

摘要

The present invention is directed to methods for identifying one or more target genes that modulate the activation state of dendritic cells. The methods are based on transfection of a siRNA library into immature bone marrow-derived dendritic cells and detecting the activation state of said cells. The identified one or more target genes can be further validated as candidate targets for induction of self-tolerance and treatment of autoimmune diseases.