| 发明名称 |
PROCESS FOR PRALATREXATE |
| 摘要 |
The present invention provides a novel process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester. The present invention also provides a novel process for the purification of pralatrexate. |
| 申请公布号 |
US2015252045(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201314436962 |
申请日期 |
2013.11.01 |
| 申请人 |
PARTHASARADHI REDDY Bandi;RATHNAKAR REDDY Kura;MURALIDHARA REDDY Dasari;SRINIVASA REDDY Katham;VAMSI KRISHNA Bandi;HETERO RESEARCH FOUNDATION |
发明人 |
Parthasaradhi Reddy Bandi;Rathnakar Reddy Kura;Muralidhara Reddy Dasari;Srinivasa Reddy Katham;Vamsi Krishna Bandi |
| 分类号 |
C07D475/08;C07C67/52 |
主分类号 |
C07D475/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester, which comprises crystallizing the alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester from a solution of alpha-propargylhomoterephthalic acid dimethyl ester containing homoterephthalic acid dimethyl ester in an ether solvent, a hydrocarbon solvent or mixture thereof. |
| 地址 |
US |
