BIOADHESIVE PATCH

摘要

A moist, layered bioadhesive patch includes one or more polymers. A method of producing a monolayered film and a method of drying said film is provided. Additionally, there is provided a method of producing bioadhesive, layered patches by combining layers of the monolayered film to obtain a desired thickness of the patch. Patches according to the invention may be used as such, or for delivering pharmaceutically active compounds, such as in a drug delivery system.

主权项

1. A method of making a moist, layered bioadhesive patch, comprising:
(a) providing an aqueous solution comprising at least one polymer selected from the group consisting of poly(methyl vinyl ether/maleic acid) and esters/amides thereof, poly(methyl vinyl ether/maleic anhydride) (PMVE/MA) and esters/amides thereof, and poly(acrylic acids) and esters/amides thereof; (b) spreading out or spraying a thin layer of the solution resulting from (a) to form a film; (c) drying the film formed; (d) applying a first layer of the film on a backing; (e) applying a second layer of the film on the first layer; (f) pressing the first layer and second layer together until the layers adhere.