NANOMATERIAL-INDUCED CYTOTOXICITY DETECTION COMPOSITION AND KIT, AND NANOMATERIAL-INDUCED CYTOTOXICITY DETECTION METHOD

摘要

The present invention concerns a detection marker which is specific to nanomaterial-induced cytotoxicity, and provides: a nanomaterial-induced cytotoxicity detection composition and kit, comprising an ERK gene which is specifically overexpressed when nanomaterial-induced cytotoxicity is present, an Egr-1 gene which is activated by the ERK gene, and an agent for measuring the level of the mRNA thereof or protein thereof; and a method for detecting nanomaterial-induced cytotoxicity by using the composition and kit. The composition, the kit and the detection method according to the present invention allow straightforward and accurate detection of cytotoxicity induced by nanomaterials comprised in, for example, the cells of nanomaterials.

主权项

1. A composition for detecting nanomaterial-induced cytotoxicity, which comprises an agent for measuring the mRNA level of ERK gene or Egr-1 gene that is activated by the ERK gene, or the level of the protein thereof.