METHODS OF IDENTIFYING COMPOUNDS FOR TREATING DEPRESSION AND OTHER RELATED DISEASES

摘要

The present disclosure relates in part to methods of identifying a candidate compound suitable for treatment of depression. In some embodiments, a candidate compound may be a NMDAR partial agonist.

主权项

1. A method for identifying a candidate compound suitable for treatment of depression, comprising:
exposing a cell to a potential compound in a culture medium, or administering a potential compound to an animal; retrieving a sample from the cell and/or culture medium, or from brain or neural tissue of the animal, at one or more predetermined time points; analyzing the sample for increased expression levels of Wnt1, and identifying the candidate compound as suitable for treatment of depression based on the increased expression level of Wnt1.