| 主权项 |
1. A novel chemical compound obtained by causing a covalent attachment of a modifying agent of the structure provided for formula 1, to a functional group or a heteroatom of a heterocyclic ring system in chemical compound With improved chemical and biological properties; Wherein: Y is DRUG-CO; DRUG-OCO; DRUG-NRCO, and X is selected from With a provisio that the modification can be done at more than one functional group in the DRUG. Alternatively: Y is DRUG-CR1R2, and X is COR, CONRR2, COOR With a provisio that the N of the drug is attached to CR1R2. With a provisio that the modification can be done at more than one functional group in the DRUG. G− can be selected from iodide, chloride, bromide, mesylate, tosylate or tetra flouroborate or any other pharmaceutically acceptable anion. G− can be either one or more counter ions to balance the charge. R, R1 and R2 are independently H, C1-C8 straight or branched chain alkyl—optionally containing 1-3 heteroatoms selected from O, N, S, SO, or SO2; 3-7 membered cycloalkyl optionally containing 1-3 heteroatoms selected from O, N, S, SO, or SO2 and or lower alkyl, straight or branched alkyl, alkoxy; alkaryl, aryl, heteroaryl, or alkheteroaryl; or is independently is independently part of 3-7 membered ring optionally containing additional 1-2 heteroatoms selected from, O, N, S, SO, SO2 and also be optionally substituted with alkoxy, F or Cl. |
