| 主权项 |
1. A compound of Formula XVI: or pharmaceutically acceptable salt thereof, wherein:
R13 and R14 are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl), heteroaryl, C3-C7 cycloalkyl, a three to twelve membered heterocyclic or aromatic ring containing up to 3 heteroatoms, each of which may be optionally substituted by from 1 to 3 substituents independently selected from halo, oxo, C1-C6 alkyl, C2-C6, alkenyl, C3-C7 cycloalkyl, C1-C6 alkoxy, CN and C1-C3 perfluoro alkyl;or R13 and R14 may be taken together form a three to twelve membered heterocyclic ring having up to 3 heteroatoms which is optionally substituted by from 1 to 3 substituents independently selected from halo, C1-C6 alkyl, C2-C6, alkenyl, C1-C6 alkoxy, C3-C7 cycloalkyl, oxo, —OH, —NH2, CN and C1-C3 perfluoroalkyl; R2 is selected from H and halo; each R3 and R4 is independently selected from the group consisting of H, C1-C8 alkyl, —CN, halo, —OH, —O—(C1-C6 alkyl), —O—(C1-C6 alkyl)-O—(C1-C6 alkyl), —NR31R32, C1-C3 perfluoro alkyl, —O—(CH2)aNR31R32, —NR31—(CH2)aNR33R34, —NR31—(CH2)aOR33, aryl, C3-C7 cycloalkyl, a three to twelve membered heterocyclic ring having up to 3 heteroatoms which is optionally substituted from 1 to 3 substituents independently selected from halo, C1-C6 alkyl, and —(C1-C6 alkyl)-O—(C1-C6 alkyl);
R31 and R32 are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, and —(C1-C6 alkyl)-O—(C1-C6 alkyl); or R31 and R32 may be taken together to form a three to twelve membered heterocyclic ring having up to 3 heteroatoms which is optionally substituted from 1 to 3 substituents independently selected from halo and C1-C6 alkyl;
R33 and R34 are independently selected from the group consisting of H and C1-C8 alkyl;a is selected from 0 to 6; R5 is selected from H and C1-C6 alkyl; R6 is selected from the group consisting of H, halo, and C1-C6 alkyl. |
