| 发明名称 |
THERAPY AND KIT FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS |
| 摘要 |
A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic, anti-inflammatory agent or a combination thereof are provided as is a method for preventing or treating cystic fibrosis. |
| 申请公布号 |
US2015250848(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201514719910 |
申请日期 |
2015.05.22 |
| 申请人 |
Trustees of Dartmouth College |
发明人 |
Madden Dean R.;Cushing Patrick R.;Boisguérin Prisca;Volkmer Rudolf;Vouilleme Lars |
| 分类号 |
A61K38/08;A61K45/06;A61K31/15 |
主分类号 |
A61K38/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for preventing or treating cystic fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that selectively inhibits the interaction between a degradation-prone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTR-Associated Ligand, thereby preventing or treating the subject's cystic fibrosis. |
| 地址 |
Hanover NH US |
