| 摘要 |
FIELD: medicine.SUBSTANCE: present invention refers to immunology. What is presented is a recovered peptide representing a fragment of CDC45L protein and having an ability to induce cytotoxic T-lymphocytes in the form of a complex with HLA-A*2402 or HLA-A*0201 molecule. There are also disclosed a polynucleotide coding the peptide according to the invention; a composition for inducing cytotoxic lymphocyte (CD8-positive T-cell, CTL) in the presence of an antigen-presenting cell (APC); a pharmaceutical composition for treating and/or preventing CDC45L-expressing tumours and/or preventing their postoperative recurrences; methods for inducing APC and CTL; the recovered APC, which represents a complex of HLA-antigen and the peptide according to the invention on its surface; a method for inducing CDC45L-expressing cancer in the individual; an expression vector of the peptide according to the invention and the host cell transformed or transfected thereby; as well as using the peptide according to the invention and APC in producing the pharmaceutical composition for treating or preventing CDC45L-expressing tumours.EFFECT: given invention can find further application in treating oncological diseases.16 cl, 8 dwg, 2 tbl |
