SPONTANEOUSLY FORMED TERMINAL SUPRAPARTICLES HAVING NANOPARTICLES FOR PROTEIN STABILIZATION

摘要

Supraparticle nanoassemblies are provided that comprise nanoparticle species and protein species, as well as methods for making such assemblies. A supraparticle may comprise a nanoparticle species with a first charge and an average particle size diameter of ≧about 1 nm to ≦about 100 nm. The supraparticle also comprises a protein species. The nanoparticle species and the protein species have the same charge and are assembled together without any intramolecular chemical bonding to form the supraparticle. The supraparticle may be a substantially round particle. In certain other aspects, a photoreactive supraparticle is provided, where the nanoparticle is reactive to energy or electromagnetic radiation, which in the presence of such energy or radiation enhances reactivity of the protein species in the supraparticle.

主权项

1. A supraparticle comprising:
a nanoparticle species having a surface with a first charge and an average particle size diameter of greater than or equal to about 1 nm to less than or equal to about 100 nm; and a protein species having a second charge that is the same as the first charge, wherein the nanoparticle species and the protein species are assembled together without any intramolecular chemical bonding to form the supraparticle.