| 发明名称 |
PEPTIDE ANTAGONISTS OF THE VASOPRESSIN-2 RECEPTOR |
| 摘要 |
The invention relates to a new group of snake venom basic protease inhibitors having vasopressin-2 receptor antagonist activity that can be used in therapy, diagnosis, medical imaging, drug screening and research. |
| 申请公布号 |
US2015252086(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201314427733 |
申请日期 |
2013.09.17 |
| 申请人 |
Commissariat A L'Energie Atomique Et Aux Energies Alternatives ;Centre National de la Recherche Scientifique (CNRS) ;Institut National De La Sante Et De La Recherche Medicale (INSERM) ;University of Regensburg ;Universite De Liege |
发明人 |
Gilles Nicolas;Servent Denis;Quinton Loïc;Reinfrank Helen;Witzgall Ralph;Mouillac Bernard;Mendre Christiane |
| 分类号 |
C07K14/46 |
主分类号 |
C07K14/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated protein, comprising an amino acid sequence which is at least 50% identical to residues 1 to 57 of SEQ ID NO: 1, and which comprises:
(i) a motif X1X2X3X4 in positions 15 to 18 of SEQ ID NO: 1, wherein X1 is an asparagine (N), X2 is a glycine (G), X3 and X4 are hydrophobic amino acids or X1 is a methionine (M), X2 and X3 are phenylalanines (F), and X4 is an Isoleucine (I), and (ii) one to three disulfide bonds between two cysteine residues, for use as vasopressin-2 receptor (V2R) antagonist in the treatment of diseases involving the V2R pathway. |
| 地址 |
Paris FR |
