| 发明名称 |
NOVEL MEK INHIBITORS FOR TREATING CARDIOMYOPATHIES AND RELATED CONDITIONS |
| 摘要 |
The invention pertains to compound of Formula (I) wherein X, Y, Z, R1, R2, R3, R4, A, and A′ are described herein. Formula (I) compounds can be used in pharmaceutical compositions, useful for the treatment of disease, in particular cardiovascular conditions and more particularly cardiomyopathies, as well as other related conditions. |
| 申请公布号 |
US2015250762(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201514683181 |
申请日期 |
2015.04.10 |
| 申请人 |
Allomek Therapeutics LLC ;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
Worman Howard J.;Muchir Antoine;Khire Uday R.;Chordia Mahendra Devichand;Hart Barry |
| 分类号 |
A61K31/395;A61K45/06 |
主分类号 |
A61K31/395 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for treating a cardiomyopathy condition in a mammal, comprising administering to said mammal, a therapeutically effective amount of the compound of Formula I, or a pharmaceutically acceptable salt, solvate or tautomer thereof. |
| 地址 |
Farmington CT US |
