FACTOR VIIa-(POLY)SIALIC ACID CONJUGATES HAVING PROLONGED IN VIVO HALF-LIFE

摘要

PROBLEM TO BE SOLVED: To provide factor VIIa-(poly)sialic acid conjugates having a prolonged in vivo half-life.SOLUTION: The present invention provides a proteinaceous construct comprising plasmatic or recombinant factor VIIa (FVIIa) or biologically active derivatives thereof, or the FVIIa or the biologically active derivatives thereof bound to a chain comprising 1-4 sialic acid units. The in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal (particularly a human), as compared to that of FVIIa or derivatives thereof without the chain comprising 1-4 sialic acid units.