| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to novel derivatives of phenylethinyl of formula (I) or to their pharmaceutically acceptable acid addition salts, possibly, in the form of a racemic mixture, or an enantiomer, that corresponds to it, and/or an optic isomer, and/or a stereoisomer. The compounds possess properties of positive allosteric modulators (PAM) of metabotropic glutamate receptors of subtype 5 (mGluR5) and can be used in the treatment of schizophrenia or cognitive disorders. In formula (I)Rrepresents hydrogen, halogen, lower alkyl or a lower alkyl, substituted with halogen; Rrepresents hydrogen, lower alkyl, =O, lower alkoxy, phenyl, hydroxy or lower alkyl, substituted with hydroxyl; X represents N, CF or CH; L represents -NR-, -NHC(R)-, -O-, -OC(R)-, -CRR-; Rrepresents hydrogen or lower alkyl, R/Rindependently on each other represent hydrogen or lower alkyl; cyc represents cycloalkyl or heterocycloalkyl, or represents a non-aromatic bicycle, selected from 7-oxa-bicyclo [2.2.1]hept-1-yl or bicyclo[2.2.1]hept-1-yl; n represents 1, 3 or 3.EFFECT: obtaining novel phenylethinyl derivatives.23 cl, 1 tbl, 44 ex |
