HUMAN ANTI-TAU ANTIBODIES

摘要

Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.

主权项

1. A human monoclonal anti-tau antibody, or a tau binding fragment thereof which
(i) is capable of binding recombinant human tau; (ii) is capable of binding pathologically modified tau; (iii) binds to pathologically aggregated tau at the pre-tangle stage, in neurofibrillary tangles (NFT), neuropil threads and/or dystrophic neurites in the brain (iv) does not substantially bind to physiological forms of tau in the brain; (v) specifically binds any one of tau isoforms B to F or fetal tau represented by SEQ ID NOs: 1 to 6; (vi) specifically binds a tau C-terminus; (vii) specifically binds a tau N-terminus (viii) specifically binds a tau epitope located in the microtubule binding domain which is masked in physiological microtubule-associated tau; (ix) specifically binds pathologically aggregated tau at the pre-tangle stage, in neurofibrillary tangles (NFT), neuropil threads and/or dystrophic neurites in the brain; (x) specifically binds a tau epitope which comprises the amino acid sequence of SEQ ID NO: 7; (xi) specifically binds a tau epitope which comprises the amino acid sequence of SEQ ID NO: 41; (xii) specifically binds a tau epitope which comprises the amino acid sequences of SEQ ID NO: 7 and 41; or (xiii) specifically binds a tau epitope which comprises the amino acid sequence of SEQ ID NO: 42.