CYSTATIN C AND GALECTIN-3 AS BIOMARKERS FOR PULMONARY ARTERIAL HYPERTENSION

摘要

Cystatin C (CysC) and Galectin 3 (Gal-3) are biomarkers for pulmonary arterial hypertension (PAH), wherein elevated levels of one or other or both CysC and Gal-3 indicates a likelihood of PAH. Also provided are methods for identifying candidates for pulmonary arterial hypertension treatment and methods for monitoring therapeutic treatments of pulmonary arterial hypertension by monitoring levels of CysC and Gal-3 in the subject undergoing therapy.

主权项

1. A method of identifying a candidate for pulmonary arterial hypertension treatment, the method comprising:
providing a sample of a biological fluid from a subject; determining the concentration of CysC and/or Gal-3 in the sample; comparing the concentration of CysC and/or Gal-3 in the sample with a normal range of CysC concentration and/or Gal-3 concentration, respectively; and determining that the concentration of CysC and/or Gal-3 is above the normal range of CysC and/or Gal-3 concentration, respectively and thereby identifying the subject as a candidate for pulmonary arterial hypertension treatment.