| 发明名称 |
METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS |
| 摘要 |
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator. |
| 申请公布号 |
US2015252094(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201514589632 |
申请日期 |
2015.01.05 |
| 申请人 |
Sangamo BioSciences, Inc. ;Board of Regents, The University of Texas System |
发明人 |
Collingwood Trevor;Cooper Laurence J.N.;Gregory Philip D.;Holmes Michael C.;Miller Jeffrey C.;Rebar Edward J.;Reik Andreas;Urnov Fyodor |
| 分类号 |
C07K14/74;A61K35/17;C12N15/90 |
主分类号 |
C07K14/74 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A genetically modified cell comprising a first genomic modification of a human leukocyte antigen (HLA) gene, the first genomic modification selected from the group consisting of an insertion, a deletion and combinations thereof such that the HLA gene is inactivated and a second genomic modification. |
| 地址 |
Richmond CA US |
