COMBINING SILDENAFIL WITH CAFFEINE IN AN ORAL DISINTEGRATING DOSAGE FORM

摘要

Pharmaceutical compositions and formulations are provided herein comprising a phosphodiesterase type 5 inhibitor, such as sildenafil citrate; and, an adenosine receptor (A1, A2A, A2B, and A3 receptors) antagonist, such as caffeine, for (i) treating erectile dysfunction while (ii) inhibiting the lower of the blood pressure, (iii) increasing the bioavailability of the compositions, and (iv) reducing the Tmax in the subject. Methods of making and administering oral disintegrating tablets are also provided.

主权项

1. A composition comprising a phosphodiesterase type 5 inhibitor (PDE5 inhibitor), or a pharmaceutically acceptable salt thereof, and caffeine, wherein the composition treats erectile dysfunction in a subject while inhibiting a lowering of blood pressure in a subject.